منابع مشابه
Inhibition of Aldose Reductase by Gentiana lutea Extracts
Accumulation of intracellular sorbitol due to increased aldose reductase (ALR2) activity has been implicated in the development of various secondary complications of diabetes. Thus, ALR2 inhibition could be an effective strategy in the prevention or delay of certain diabetic complications. Gentiana lutea grows naturally in the central and southern areas of Europe. Its roots are commonly consume...
متن کاملInhibition of aldose reductase and sorbitol accumulation by dietary rutin
Accumulation of intracellular sorbitol due to increased aldose reductase (ALR2 or AKR1B1) activity has been implicated in the development of various secondary complications of diabetes. Previously we have reported that some common dietary sources such as spices, fruits and vegetables have the potential to inhibit ALR2 under in vitro conditions and in animal models. In this study, we describe th...
متن کاملinhibition of aldose reductase and red blood cell sorbitol accumulation by extract of capparis spinosa
conclusions these results demonstrated that cse, mainly through inhibition of alr2, could prevent or delay the diabetic complications, like cataract formation, as a result of sorbitol accumulation. results the cse inhibited alr2 activity, with an ic50 of 0.54 mg/ml and it was seven and a half times greater than that of alr1 inhibition, indicating the specificity of cse for alr2, rather than alr...
متن کاملinhibition of aldose reductase and sorbitol accumulation by hydroalcoholic extract of propolis
materials and methods total protein was determined by lowery method. bovine lens alr2 was partially purified by gel filtration chromatography on sephadextm g25. bovine cortex kidney alr1 was partially purified by diethylaminoethyl (deae) precipitation. the hydroalcoholic extract was obtained from frozen propolis. the enzyme activity and sorbitol accumulation in erythrocytes were determined spec...
متن کاملPrevention of posterior capsular opacification through aldose reductase inhibition.
PURPOSE The purpose of this study was to evaluate the effect of aldose reductase (AR) inhibition on posterior capsular opacification (PCO) with the use of a pig eye capsular bag model. METHODS Pig eye capsular bags were prepared by capsulorhexis and cultured in medium without or with AR inhibitors for 7 days. Immunostaining was performed in paraformaldehyde-fixed capsular bags to determine th...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1984
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.32.767